Description. For cats, tubes/pipettes are available in sizes of 0.23 ml ( for cats and kittens from 2 –5 pounds) 0.4 ml (for cats 5.1 – 9 pounds) and 0.8 ml (for cats 9.1 18 pounds). The following adverse events in dogs are listed in decreasing order of reporting frequency: depression/lethargy, vomiting, pruritus, diarrhea, anorexia, hyperactivity, ataxia, trembling, hypersalivation, application site reactions (alopecia, pruritus, lesions, and erythema), seizures, and anaphylaxis/anaphylactic reactions (hives, urticaria, facial swelling, edema of the head). Topical imidacloprid/moxidectin combination treatment administered 3 times at 28-day intervals, or more frequently, did not eliminate mites from most treated dogs. Do not let this product get in your dog’s mouth or eyes. Twist the cap to break the seal and then remove cap from the tube. For dogs, the recommended minimum dose is 4.5 mg/lb. (imidacloprid + moxidectin) Topical Solution. Side effects are uncommon but may include irritation at the application site, or, if the medication is accidentally ingested, drooling, shaking, vomiting, and decreased appetite. If a dose is missed and a 30-day interval between doses is exceeded, administer Advantage Multi for Dogs immediately and resume the monthly dosing schedule. Have person sip a glass of water if able to swallow. Do not get in eyes or on clothing. Prior to administration of Advantage Multi for Dogs, dogs should be tested for existing heartworm infection. Not for human use. All dogs were hospitalized for a minimum of 12 hours following each treatment. Dog medications dosage requirements are generally calculated by weight and measured in mg of medicine per pound of body weight. Tubes/pipettes are available in sizes of 0.4 ml (for dogs 3-9 pounds), 1 ml (for dogs 9.1 – 20 pounds), 2.5 ml (for dogs 20.1 to 55 pounds), and 4 ml (for dogs over 55.1 to 88 pounds). Three dogs treated with Advantage Multi for Dogs in a dosing regimen with melarsomine dihydrochloride died of pulmonary embolism from dead and dying heartworms. Advocate Topical Solution for Dogs and Cats (with Moxidectin) Advantix Topical Solution for Dogs and Cats (with Permethrin) Seresto Collar for Dogs and Cats (with Flumethrin) Generic products are available. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. (See WARNINGS.). The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration. Toxic Dose. Start to kill adult fleas within 1 hour. The safety of Advantage Multi for Dogs has not been evaluated when administered on the same day as an adulticide. The safety of Advantage Multi for Dogs has not been established in breeding, pregnant, or lactating dogs. Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. Dogs treated with imidacloprid, including those with pre-existing flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the dog. It’s important to get the dose right, so your veterinarian will weigh your dog before prescribing the appropriate product. Dogs over 88 pounds should be treated with the appropriate combination of tubes. Effectiveness against circulating D. immitis microfilariae was > 90% at five of six sites; however, one site had an effectiveness of 73.3%. Multiply 0.045 times your dog’s weight for more precise dosage. LD50 acute, rats, dermal >5000 mg/kg As a general rule, dogs and cats tolerate imidacloprid very well. Field Study: In a controlled, double-masked, field safety study, Advantage Multi for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. ● For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. The dose of imidacloprid is based on the weight of the dog. 5. Observations at the application sites included damp, stiff or greasy hair, the appearance of a white deposit on the hair, and mild erythema, which resolved without treatment within 2 to 48 hours. The recommended minimum doses for dogs are 10mg/kg bodyweight imidacloprid and 2.5mg/kg body weight moxidectin, equivalent to 0.1ml/kgbody weight Endectrid for dogs. For dogs weighing 20 lbs. The following adverse events are based on post-approval adverse drug experience reporting. In dogs the LD 50 is 450 mg/kg of body weight (i.e., in any sample of medium-sized dogs weighing 13 kilograms (29 lb), half of them would be killed after consuming 5,850 mg of imidacloprid, or about ​ … Imidacloprid is a topical agent and temporary irritation at the site of application is possible. Even if your pet appears to feel better, the entire treatment program should be completed to prevent resurgence of the infestation. Description. It is supplied as a topical solution that collects in the oils of the skin and in hair follicles. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. Box 390, Shawnee Mission, Kansas 66201 U.S.A. Safety Study in Puppies: Advantage Multi for Dogs was applied topically at 1, 3 and 5X the recommended dose to 7-week-old Beagle puppies once every 2 weeks for 6 treatments on days 0, 14, 28, 42, 56, and 70. Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Advantage Multi for Dogs in the treatment of flea infestations. Wash hands thoroughly with soap and warm water after handling. Information contained on this site pertains only to the United States of America, and is not intended to provide adequate information for product use. canis, Advantage Multi for Dogs should be administered as a single topical dose. Veterinary formulations: Advantage Multi® (Bayer). How it Works: Advantus Oral Flea Treatment Capsules for Dogs contain Imidacloprid, which safely and effectively kills fleas within one hour of administration and is 96% effective against adult fleas within 4 hours.The capsule is easy to give to your dog and may be given as an occasional dose when you see fleas on your pet or daily if necessary. *Dogs over 110 lbs. advantus is available in two strengths: 7.5 mg for dogs weighing 4-22 lbs. ©Copyright 1999 - 2021. However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas. In cats, moxidectin is dosed at 10 mg/kg imidacloprid with 1 mg/kg moxidectin (Advantage® Multi) applied topically every 30 days. Following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride, the following adverse reactions were observed: Dogs Treated with Advantage Multi for Dogs Only n=106, Dogs Treated with Advantage Multi for Dogs + Melarsomine n=108. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites. In dogs, injectable moxidectin is dosed at 0.023 mg per pound (0.05 mg/kg) intramuscularly every 6 months. For a copy of the Safety Data Sheet (SDS) or to report adverse reactions call Bayer Veterinary Services at 1-800-422-9874. Flea Treatment: For the treatment of flea infestations, Advantage Multi for Dogs should be administered at one-month intervals. canis. Using the correct dosage about 15 CC's will work... like i said above , it didn't work very well for me on ticks, but it will kill fleas. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. The microfilariae count in some heartworm-positive dogs increased or remained unchanged following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride. Laboratory Safely Study in Heartworm-Positive Dogs: Advantage Multi for Dogs was administered topically at 1 and 5X the recommended dose every 14 days for 3 treatments to dogs with adult heartworm infections and circulating microfilariae. (2.5 mg/kg) moxidectin, once a month, by topical administration. In a field safety and effectiveness study, Advantage Multi for Dogs was administered to 92 client-owned dogs with sarcoptic mange. In avermectin sensitive dogs,a the signs may be more severe and may include coma and death.b. Not all adverse reactions are reported to FDA CVM. No clinical abnormalities were observed. If contact with skin or clothing occurs, take off contaminated clothing. Efficacy of topically administered fluralaner or imidacloprid/moxidectin on dogs with generalised demodicosis Use with caution in sick, debilitated, or underweight animals. It is frequently used in combination with other medications to treat a variety of parasites. What is this drug? (10 mg/kg) imidacloprid and 1.1 mg/lb. Both have the same formula containing 1.47 percent Imidacloprid just like the Bayer Tree and Shrub Insect Control. Owners reported the following signs in their dogs after application of Advantage Multi for Dogs: pruritus, flaky/greasy residue at the treatment site, medicinal odor, lethargy, inappetence, and hyperactivity. The chemical name for imidacloprid is 1-[(6-Chloro-3-pyridinyl)methyl]-N-nitro-2-imidazolidinimine. We comply with the HONcode standard for trustworthy health information -, Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs Indications, Warnings and cautions for Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs, Direction and dosage information for Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs. Regulations for product use are established by country. Do not apply to irritated skin. Avoid contact with skin. No fleas and no problems. Advantage Multi for Dogs is not effective against adult D. immitis. Dogs with this mutation may develop signs of severe avermectin toxicity if they ingest this product. Cats over 18 pounds should be treated with the appropriate combination of tubes. It is not absorbed into the body and does not circulate through the blood stream. Moxidectin has been shown to be safe in collie breeds and collie mixed breeds. The Collies were asymptomatic after ingesting 10% of the minimum labeled dose. (See WARNINGS.). In case of allergic reaction, contact a physician. Call a poison control center or physician for treatment advice. Due to its bitter taste, this drug may cause temporary profuse drooling if ingested. Ivermectin has a very wide safety range; dosage for dogs with demodex is 300 mcg/kg, and this amount may be given daily over weeks or months. The active ingredient in Bayer Tree & Shrub is 1.47% imidacloprid - the same ingredient which they market in Advantage flea control for dogs in a 9.1% solution. Food Residue Two puppies each in the 1X, 3X, and 5X groups had decreased appetites within 24 hours post-dosing. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Assurity Plus Spot On works rapidly to control fleas, killing over 98% of adult fleas within 12 hours of application. Imidacloprid and moxidectin should not be used in animals with known hypersensitivity or allergy to the drug. How it Works: Advantus Oral Flea Treatment Capsules for Dogs contain Imidacloprid, which safely and effectively kills fleas within one hour of administration and is 96% effective against adult fleas within 4 hours.The capsule is easy to give to your dog and may be given as an occasional dose when you see fleas on your pet or daily if necessary. 7.5 mg Advantus Soft Chews contain 7.5 mg imidacloprid per chew for dogs 4 - 22 lbs. Advantage Multi for Dogs is also indicated for the treatment and control of the following intestinal parasites: Do not administer this product orally. This drug should only be used in dogs after a negative heartworm test. The dogs ranged in age from 2 months to 12.5 years and ranged in weight from 3 to 231.5 pounds. It is primarily used to prevent heartworm infection. Dogs in the treated group did not gain as much weight as the control group. Advantage Multi for Dogs has not been evaluated in heartworm-positive dogs with class 4 heartworm disease. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Multiply 0.045 times your dog’s weight for dose The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration. The dose of imidacloprid is based on the weight of the dog. Both strengths are available in 7-count or 30-count bottles. The adult dosage for most cats is 0.4 mL of the imidacloprid oil. Even the biggest dose, for dogs over 40kg, is less than a teaspoon. Treatment and Control of Intestinal Nematode Infections: For the treatment and control of intestinal hookworm infections caused by Ancylostoma caninum and Uncinaria stenocephala (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara canis (adults and fourth stage larvae), and Toxascaris leonina (adults), and whipworm infections caused by Trichuris vulpis (adults), Advantage Multi for Dogs should be administered once as a single topical dose. a Some dogs are more sensitive to avermectins due to a mutation in the MDR1 gene. It is important to note that the dog product should only be used on dogs while the cat product should only be used on cats. Consult with your veterinarian to determine if other drugs your pet is receiving might interact with imidacloprid and moxidectin. This drug is registered for use in animals only. (See ADVERSE REACTIONS.). After application latest medication news, new drug approvals, alerts and updates,... 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